fa تحقيقي Original Paper <div>&nbsp; <div><strong>ABSTRACT</strong><br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objectives: </strong>Nowadays, the prevalence of multidrug-resistant pathogens such as <em>Pseudomonas aeruginosa</em> is increasing worldwide. Many studies have been seeking new treatment strategies to treat infections caused by these microorganisms. Silver nanoparticles (AgNPs) along with L-arginine have significant antimicrobial effects and could be used as alternatives for ineffective drugs.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Methods: </strong>In this study, the antibacterial activity of AgNPs, L-arginine and various concentrations of AgNPs along with L-arginine (12.5 and 25 mg/ml) were investigated against <em>P. aeruginosa </em>PAO1 using the broth macrodilution method.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Results:</strong> Minimum inhibitory concentration of AgNPs, L-arginine and AgNPs combined with 25 and 12.5 mg/ml L-arginine was 15.6 &mu;g/ml, 25 mg/ml, 1.9 &mu;g/ml and 3.9 &mu;g/ml, respectively. Minimum bactericidal concentration of AgNPs, L-arginine and AgNPs combined with 25 and 12.5 &nbsp;mg/ml L-arginine was 31.2 &mu;g/ml, 50 mg/ml, 3.9 &mu;g/ml and 7.8 &mu;g/ml, respectively.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Conclusion: </strong>Our study suggests that AgNPs along with L-arginine can be used as an alternative antibacterial agent against <em>P. aeruginosa</em>, and might be useful for treatment of wound infections.<span dir="RTL"></span><br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Keywords:</strong> Nanoparticles, Arginine, <a href="https://www.ncbi.nlm.nih.gov/mesh/68000900">Anti-Bacterial Agents</a>, <em>Pseudomonas aeruginosa</em>.&nbsp;</div> </div> Nanoparticles, Arginine, Anti-Bacterial Agents, Pseudomonas aeruginosa. 7 11 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-495&slc_lang=fa&sid=1 Mina Parsa parsamina26@gmail.com 100319475328460013879 100319475328460013879 Yes Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Malahat Ahmadi 100319475328460013880 100319475328460013880 No Professor of Bacteriology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Habib Dastmalchi 100319475328460013881 100319475328460013881 No Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Aliasghar Tehrani 100319475328460013882 100319475328460013882 No Department of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran