Medical Laboratory Journal

fa Efficacy of Mupirocin Ointment in Eradication of Staphylococcus aureus Nasal Carriage in Intensive Care Unit Staff and Patients تحقيقي Original Paper <div> <div>ABSTRACT           Background and Objectives: Staphylococcus aureus is one of the most common causes of morbidity and mortality among intensive care unit (ICU) patients. Nasal carriage is one of the main routs of S. aureus transmission between hospital personnel and patients. The objective of this study was to evaluate the efficacy of mupirocin ointment in eradication of nasal carriage of S. aureus in the ICU staff and patients of Panje-Azar hospital in Gorgan, Iran.           Methods: In the first three months of the study (January to March), the prevalence of S. aureus among ICU patients was determined by routine microbiological and biochemical testing. Nasal samples were taken from ICU staff and all patients recently admitted to the ICU. Mupirocin nasal ointment (2%) was applied for treatment of S. aureus nasal carriers. Post-treatment sampling was done after five weeks. During the next three months, the presence of S. aureus and rate of resistance to methicillin was evaluated in new patients admitted to the ICU using the method used previously.           Results: Of 60 samples from the ICU staff, seven (11.7%) samples were positive for S. aureus. Moreover, of 240 samples from the ICU patients, two samples were found as S. aureus-positive. Of the nine S. aureus-positive isolates, only two (22.2%) were methicillin-resistant S. aureus (MRSA). In the pre-intervention sampling, only five samples (2.8%) were identified as S. aureus, two of which were MRSA. However, treatment with mupirocin ointment eradicated nasal carriage of S. aureus and no isolate was found after the intervention.           Conclusion: Our finding showed that mupirocin nasal ointment is highly effective in eradication of S. aureus nasal carriage and subsequently contribute to reduction in frequency of nosocomial infections in the ICU.           Keywords: <a href="https://www.ncbi.nlm.nih.gov/mesh/68007362">Intensive Care Units</a>, Mupirocin, Nasal, <a href="https://www.ncbi.nlm.nih.gov/mesh/68013211">Staphylococcus aureus</a>.</div> </div> Intensive Care Units, Mupirocin, Nasal, Staphylococcus aureus. 12 16 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-516&slc_lang=fa&sid=1 Abolfazl Khandan del 100319475328460014877 0000000278662296 Yes Department of Microbiology, 5th Azar Hospital, Golstan University of Medical Sciences, Gorgan, Iran Ania Ahani Azari 100319475328460014878 100319475328460014878 No Department of Microbiology, Gorgan branch, Islamic Azad University, Gorgan, Iran Ailar Jamalli 100319475328460014879 100319475328460014879 No Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran Ezzat Allah Ghaemi eghaemi@yahoo.com 100319475328460014880 100319475328460014880 No Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran