Medical Laboratory Journal

fa Antibacterial and Ciprofloxacin-Potentiation Activities of Cinnamomum zeylanicum Extracts against Some Pathogenic Bacteria فیزیولوژی ورزشی Sport Physiology تحقيقي Original Paper <div>ABSTRACT              Background and Objectives: Efflux-based systems may play a role in resistance to fluoroquinolones in Gram-negative pathogenic bacteria. Extracts of some medicinal plants contain molecules that can act as efflux pumps inhibitors. In this study, we aimed to evaluate antibacterial activities of ethanolic and chloroform extracts of Cinnamomum zeylanicum and their possible synergistic activity with ciprofloxacin against some Gram-negative pathogenic bacteria. We also analyzed the extracts for presence of efflux pump inhibitors against the examined bacteria.              Methods:  Powdered dried leaves and branches of C. zeylanicum were extracted with ethanol (85%) and chloroform by the maceration method. Minimum inhibitory concentrations of the extracts alone or combined with ciprofloxacin and phenylalanine-arginine β-naphthylamide (an efflux pump inhibitor) were determined against Pseudomonas aeruginosa, Acinetobacter bummani, Escherichia coli and Salmonella enteritidis using the double serial microdilution method.              Results: The extracts of C. zeylanicum inhibited the growth of all studied bacteria. Synergistic effects were noted between the extracts and ciprofloxacin against all tested bacteria other than P. aeruginosa. Ciprofloxacin efflux pumps in E. coli, S. enteritiditis and A. baumannii were inhibited by the extracts of C. zeylanicum.              Conclusion: The extracts of C. zeylanicum could be used as ciprofloxacin-potentiating agents against some Gram-negative pathogens.              Keywords: Anti-bacterial agents, Cinnamomum zeylanicum, Bacterial pathogens, Efflux pumps.</div> Anti-bacterial agents, Cinnamomum zeylanicum, Bacterial pathogens, Efflux pumps. 6 10 http://mlj.goums.ac.ir/browse.php?a_code=A-10-590-4&slc_lang=fa&sid=1 Azizollah Ebrahimi 100319475328460015615 100319475328460015615 Yes Department of Pathobiology, School of Veterinary Science, Shahrekord University, Shahrekord, Iran Azimeh Babaaie 100319475328460015616 100319475328460015616 No DVM Student of Pathobiology Department, Veterinary College, Shahrekord University, Iran Mojtaba Boniadian 100319475328460015617 100319475328460015617 No Department of Public Health, School of Veterinary Science, Shahrekord University, Shahrekord, Iran Sharareh Lotfalian 100319475328460015618 100319475328460015618 No Sharareh Lotfalian