en آسيب شناسي Pathology تحقيقي Original Paper Introduction: COVID 19 pandemic caused by SARS-COV2 virus has taken a toll all over the world. The susceptibility of various diseases like <em>Helicobacter Pylori, Hepatitis B virus and Norwalk Virus </em>and even SARS Corona Virus 1 have been associated with ABO blood groups. However, very limited data is available regarding the COVID 19 susceptibility and ABO blood groups. Methods: In the present report we investigated 500 admitted patients who were RTPCR positive for corona virus. Significant Tests were applied to study association of blood groups vis a vis disease severity, ICU admissions and assisted ventilation. Results: &nbsp;We found out that Type A blood group is more susceptible to severe COVID 19 infection, even though maximum patients were of type B blood group. We also found that type A blood group needed more ICU admission and assisted ventilation then non type A groups and difference was statistically significant. Conclusion: Patients with type A blood group COVID 19 patients with type A blood group might require more vigilant surveillance and aggressive treatment measures. Further studies are required to validate the disease susceptibility. ABO Blood-Group System,COVID-19,Disease Susceptibility,SARS-CoV-2, 1 7 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1086-1&slc_lang=en&sid=1 Bhumika Gupta drbhumigupta@gmail.com 100319475328460020952 100319475328460020952 No Department of Pathology, Government Institute of Medical Sciences, Greater Noida, U.P, India Shivani Kalhan shivani.kalhan69@gmail.com 100319475328460020953 100319475328460020953 No Department of Pathology, Government Institute of Medical Sciences, Greater Noida, U.P, India Shalini Shukla shalini.bahadur2008@rediffmail.com 100319475328460020954 100319475328460020954 Yes Department of Pathology, Government Institute of Medical Sciences, Greater Noida, U.P, India Shalini Bahadur drshalinishukla.8@gmail.com 100319475328460020955 100319475328460020955 No Department of Pathology, Government Institute of Medical Sciences, Greater Noida, U.P, India Gyanendra Singh gyanendra002@gmail.com 100319475328460020956 100319475328460020956 No Department of Pathology, Government Institute of Medical Sciences, Greater Noida, U.P, India Rambha Pathak rambha.pathak@gmail.com 100319475328460020957 100319475328460020957 No Department of Community Medicine, Government Institute of Medical Sciences, Greater Noida, U.P, India