en بیوشیمی Biochemistry Research Article Research Article <span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> The complete blood count (CBC) profile has been found extremely useful in monitoring the growth of SARS-CoV-2 infection; however, predictive CBC parameters that could be used in the management of the disease may vary in different populations.<br> <b>Methods:</b> This study comparatively analyzed the CBC profile of SARS-CoV-2 patients (N = 75; confirmed positive by real-time polymerase chain reaction [PCR]) and healthy individuals (confirmed negative by real-time PCR) from Kashmir (north India).<br> <b>Results:</b> Compared with healthy individuals, most of the CBC parameters (hemoglobin levels [13.43 vs 10.9 g/dL; P = 0.0001], lymphocytes [16.04% vs 30.8%; P = 0.00001], monocytes [5.53% vs 7.53%; P = 0.009], and platelet count [150 vs 186 &times;103 &micro;L; P = 0.037]) were significantly low in SARS-CoV-2 infected patients, while neutrophilia was more common in infected patients (76.77% vs 59.26%). Among derived parameters, the neutrophil-to-lymphocyte ratio (NLR; 7.31 vs 2.04; P = 0.001) and derived NLR (d-NLR; 4.43 vs 1.5; P = 0.0002) were significantly high in SARS-CoV-2 patients. Further correlation analysis revealed a significant association of neutrophilia with the severity of the disease in SARS-CoV-2 infected patients. Moreover, receiver operating characteristic (ROC) analysis of derived CBC parameters (NLR, d-NLR, and platelet‐to-lymphocyte ratio [PLR] with disease severity and disease outcome) revealed d-NLR as better predictive marker of disease severity (area under the curve [AUC] = 0.658) and disease outcome (AUC = 0.766) compared to PLR with disease severity (AUC = 0.645) and disease outcome (AUC = 0.693).<br> <b>Conclusion</b>: We therefore conclude, of the CBC parameters neutrophilia as the marker of disease severity and among derived parameters, d-NLR as an early predictive biomarker of both disease severity and poor disease outcome in SARS-CoV-2 patients.</span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span> SARS-CoV-2,Neutrophilia,Disease severity ,Disease outcome 4 8 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1426-1&slc_lang=en&sid=1 Ifrah Jan ifrahreshi9@gmail.com 100319475328460027228 100319475328460027228 Yes Department of Clinical Biochemistry University of Kashmir, Hazratbal, Srinagar, Kashmir, J&K India Rafiqa Eachkoti 100319475328460027229 100319475328460027229 No Department of Biochemistry Govt Medical College and associated hospitals, Karan Nagar, Srinagar, Kashmir, J&K India Iqra Farooq 100319475328460027230 100319475328460027230 No Department of Biochemistry Govt Medical College and associated hospitals, Karan Nagar, Srinagar, Kashmir, J&K India Sanah Farooq 100319475328460027231 100319475328460027231 No Department of Biochemistry Govt Medical College and associated hospitals, Karan Nagar, Srinagar, Kashmir, J&K India Sadaf Saleem 100319475328460027232 100319475328460027232 No Department of Biochemistry Govt Medical College and associated hospitals, Karan Nagar, Srinagar, Kashmir, J&K India Sabhiya Majid 100319475328460027233 100319475328460027233 No Department of Biochemistry Govt Medical College and associated hospitals, Karan Nagar, Srinagar, Kashmir, J&K India