Medical Laboratory Journal

en Investigation of the simultaneous effect of resistance training and atorvastatin in improving nonalcoholic fatty liver disease in Wistar rats fed high high-fat/fructose diet فیزیولوژی ورزشی Sport Physiology Research Article Research Article <div style="text-align: justify;">Background: Non-alcoholic fatty liver disease (NAFLD), a highly prevalent and chronic liver disease, is characterized by a diverse range of conditions that span across a broad spectrum. Engaging in consistent physical activity has proven to be a successful method in effectively managing NAFLD, as it has demonstrated the ability to enhance crucial elements implicated in the development of the condition. Methods: Twenty-one male Wistar rats were divided into three groups: 1. NAFLD, 2. NAFLD + resistance training (RT), and 3. NAFLD + RT + atorvastatin (ATO). The groups received high-fat/fructose diet (HFFD) to induce NAFLD and it was confirmed through evaluation of histopathological analysis (H&E staining) and measurement of aminotransferase enzymes. ATO was administrated at a dose of 2 mg/kg/day. The interventions were carried out over eight weeks. Results: Triglyceride (TG), Alanine transaminase (ALT), and aspartate transaminase (AST) were significantly reduced in the NAFLD + RT + ATO group. Additionally, low-density lipoprotein (LDL) levels were lower in NAFLD + RT group than NAFLD + RT + ATO group. Alkaline phosphatase (ALP) was reduced in both NAFLD + RT and NAFLD + RT + ATO groups compared to NAFLD. There was no significant difference in weight between the groups except the first, second, and fourth weeks. Conclusion: Resistance training in combination with the administration of ATO can be deemed as an efficacious and supplementary strategy to effectively control and address NAFLD.</div> Non-alcoholic fatty liver disease, Resistance training, Lipids, Atorvastatin, Liver enzymes 48 52 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1578-1&slc_lang=en&sid=1 Raouf Moradian raoufmoradian1364@gmail.com 100319475328460030682 0009-0000-7557-2491 No Department of Physical Education and Sports Sciences Central Tehran Branch, Islamic Azad University, Tehran, Iran Amir Haji Ghasem amir.hajighasem01@gmail.com 100319475328460030683 100319475328460030683 Yes Department of Physical Education and Sports Sciences Central Tehran Branch, Islamic Azad University, Tehran, Iran Saleh Rahmati salehrahmati@pardisiau.ac.ir 100319475328460030684 100319475328460030684 No Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran Lida Moradi moradi.lida@gmail.com 100319475328460030685 100319475328460030685 No Department of Physical Education and Sports Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran