fa تحقيقي Original Paper <div> <p><strong>ABSTRACT</strong></p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objective: </strong><em>Glycyrrhizaglabra</em> L. is one of the most widely used medicinal herbs&nbsp;in Golestan province that is known for its anti-inflammatory, carminative, antiviral, anti-infection and anti-ulcer properties in Iranian traditional medicine. This study aimed to assess the anti-bacterial and anti-oxidative activity of <em>G. glabra</em>from the Golestan province.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Methods:</strong>&nbsp; The rip root of the plant was collected in autumn 2013. The ethanolic extract of the plant was prepared by maceration method. The anti-oxidative property of the plant was assessed by total antioxidant capacity (TAC), reducing power (RP) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity assays. The anti-bacterial activity was assessed using agar-well diffusion method and the minimum inhibitory concentration (MIC) assay.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Results: </strong>The ethanolic extract of <em>G. glabra</em>had relatively high anti-oxidative activity with IC50 value of 130 &micro;g/ml, especially in the DPPH method. The extract also exhibited high anti-bacterial activity against the following Gram-positive bacteria: <em>Staphylococcus aureus</em> (21.1&plusmn;0.7 mm), <em>Staphylococcus epidermidis</em> (19.6&plusmn;0.2 mm), <em>Bacillus subtilus</em> (19.3&plusmn;0.6 mm), followed by <em>Escherichia coli</em> (12.1&plusmn;0.8 mm), <em>Enterococcus faecalis</em> (13.2&plusmn;0.1 mm) and <em>Kelebsiellapneumoniae</em> (11.5&plusmn;0.4 mm) with MIC values in the range of 31 - 132 mg. mL^-1.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Conclusion</strong>: According to results, the root extract of <em>G.glabra</em>is a good source of antioxidant compounds with suitable anti-bacterial activity, which can be used as natural anti-infection and anti-inflammatory agent for treatment of many diseases.</p> <p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </strong></p> </div> <p></p> Anti-Bacterial, Anti-Oxidant, Glycyrrhiza, Golestan Province. 48 52 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-405&slc_lang=fa&sid=1 Ali Varasteh Moradi avmoradi@yahoo.com 100319475328460010793 100319475328460010793 Yes Department of Microbiology Sedigheh Zhand 100319475328460010794 100319475328460010794 No Department of Microbiology