Eliz Thomas , Nidhya Ganesan , Lawanya Gunaseelan , Subbarao Tadury Madhukar ,
Volume 19, Issue 3 (5-2025)
Abstract
Background: This study aimed to analyze the hematological parameters in pregnant women who were COVID-positive in a tertiary care hospital and to observe whether there was an association between the findings and disease severity.
Methods: This retrospective study included 64 COVID-positive pregnant patients who were admitted to our hospital, under the obstetrics department, during the period from June 2020 to December 2020. The hematological parameters, such as hemoglobin, MCV, RDW, etc., of these women during the third trimester were assessed, and the outcome of the pregnancy was recorded.
Results: Among 64 COVID-positive pregnant women, 14 complained of the usual symptoms like fever, cough, or headache. One complained of increased breathlessness. After hematological work-up, 46 (72%) patients were recorded to have anemia, and 38 (59%) showed leukocytosis. Neutrophilia was seen in 34 patients. The platelet count was within normal limits for all. Forty-nine of them underwent caesarean section for various reasons, the most common being previous caesarean section. Sixty-two deliveries were done at term. Only one of the babies delivered had anemia at birth. The 1- and 5-minute APGAR scores recorded for all the babies were 7 to 9. Fifteen babies delivered underwent RT-PCR testing and were found to be negative.
Conclusion: The laboratory parameters most commonly seen among the COVID-19 pregnant women were anemia, leukocytosis, and neutrophilia, which are comparable to the physiological changes in pregnancy. There was no adverse outcome observed in any of the pregnancies, and all the fetuses were normal. There was no incidence of vertical transmission of the virus among the tested neonates.
Mr Joseph Raymond Enoghase, Dr Silvanus Olu Innih,
Volume 20, Issue 3 (7-2026)
Abstract
Background: Mercury chloride is a well-established toxicant known to induce hematological alterations, including oxidative hemolysis, anemia, and thrombocytopenia. Medicinal plants with antioxidant properties have been explored as potential protective agents against toxicant-induced damage. Anthocleista djalonensis, widely used in traditional medicine, has been reported to possess bioactive compounds with therapeutic potential. This study aimed to investigate the role of Anthocleista djalonensis in mitigating mercury chloride-induced hematological alterations.
Methods: This experimental randomised controlled animal study was kind of weirdly done, with thirty-six adult Wistar rats, randomly assigned into six groups, (n=6 each). Group A was basically the control, Group B got only 2 mg/kg of mercury chloride , just that. Groups C and D were given mercury chloride alongside 150 mg/kg and 300 mg/kg of Anthocleista djalonensis extract, respectively , while Groups E and F received just A. djalonensis at doses 150 mg/kg and 300 mg/kg. The extract was freeze dried, and then the haematological parameters were checked using an automated haematology analyser. For the statistics, it was handled with one-way ANOVA, and the significance cut off was p < 0.05.
Results: Mercury chloride exposure significantly reduced red blood cell count, hemoglobin concentration, and platelet levels, indicating hematotoxicity. Co-administration with A. djalonensis, particularly at 150 mg/kg, significantly improved these hematological indices, suggesting a protective effect. The plant extracts also enhanced mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, indicating potential erythropoietic support.
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