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Showing 2 results for Myocardial Infarction
Plasma Level of Homocysteine, Folic acid and Cobalamine in Patients suffered from myocardial infarction
Hr Joshaghani, Aa Shirafcan, Aj Marjani,
Volume 1, Issue 2 (10-2007)
Abstract

Abstract

Introduction:

methionine. Many reports confirm the correlation between hyper

homocysteinemia and cardiovascular disease. This study was aimed

at determining the effect of B12 and folate deficiency on the

homocysteine level after myocardial infarction.

Homocysteine is produced by demethylation of

Materials and methods:

study were patients with myocardial infarction (N = 48) and healthy

patients (N = 48) Eliza method was used to assay Homocysteine and

RIA for folic acid and vitamin B12.

The subjects of This descriptive-analytic

Results:

(30.3 ± 5.3 μm/l) and the control group (11.1 ± 3.1) is significant (p<

0.001). There is no significant difference between Serum B12 in case

(297.1 ± 208.9 pm/l) and control group (261.5 ± 205.3) and it is true

about Serum folic acid of case (3.9 ± 2.9 ng/m) and control group

(4.3 ± 3.5). The homocysteine level of all patients and four of

healthy subjects is higher than normal. The folic acid Level of 11

patients and four healthy subjects is less than normal.

the difference between the homocysteine Level of the case

Conclusion:

of control group and this difference is not related to decrease of B12

Level, Physicians must pay attention to The other risk factors.

since the homocysteine level of patients is there times

Key words:

cobalamine, cardiovascular disease.

Folic acid, Homocysteine, Myocardial Infarction,
Effects of Resistance Training Following Bone Marrow Stem Cell Transplantation on Cardiac Oxidative Stress and Left Ventricular Function in a Rat Model of Myocardial Infarction
Mr Hossein Mahdian, Dr Seyed Abdollah Hashemvarzi, Dr Kamal Ranjbar,
Volume 20, Issue 2 (6-2026)
Abstract
Background and objectives: This study aimed to evaluate the effects of resistance training following bone marrow stem cell transplantation, a regenerative approach targeting damaged cardiac tissue, on myocardial oxidative stress markers and left ventricular function in a rat model of myocardial infarction (MI).
Methods: Sixty male Wistar rats (7–8 weeks old) were randomly assigned to six experimental groups (n=10 per group): healthy control, MI control, sham, stem cell, exercise, and exercise + stem cell. MI was induced by permanent ligation of the left anterior descending coronary artery. Stem cells (1×10⁶) were injected via the tail vein. Resistance training protocol consisted of climbing sessions performed five days per week for six weeks. Each session included three sets of five repetitions, with a one-minute rest interval between sets. Oxidative stress markers (CAT and MDA) were analyzed biochemically, and left ventricular function was assessed by echocardiography. Data were analyzed using one-way ANOVA and Tukey’s post hoc test.
Results: MDA levels were significantly increased and CAT levels decreased in the MI group compared to controls. Resistance training and combined therapy significantly reduced MDA levels; however, CAT changes were not statistically significant. Cardiac output and ejection fraction were significantly improved in the intervention groups compared to the MI group.
Conclusion: Six weeks of resistance training after bone marrow stem cell transplantation effectively reduced oxidative stress and improved left ventricular function in MI rats. This combined approach may serve as a promising therapeutic strategy for myocardial infarction recovery.
 
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